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Lancet 402(10401):529544 Clinical trial.gov [Home page in Internet] A study of retatrutide (LY3437943) in participants with obesity and cardiovascular disease (TRIUMPH-3)

Energy expenditure and metabolic rate endpoints: Retatrutide is the more informative compound because GCGR signaling is mechanistically linked to thermogenesis and hepatic substrate handling in preclinical models

doi:10.1016/j.cgh.2017.04.016

We have previously described a 30% increase in myocardial flow reserve [8] and we speculate that SGLT-2i treatment, by restoring the anti-inflammatory properties of EAT, improves coronary microvascular dysfunction, leading to an amelioration of myocardial flow reserve [9]

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